| abstract |
The invention discloses a preparation method of piperazine compounds and intermediates thereof, belonging to the field of drug synthesis. The compounds and their intermediates can be used to prepare drugs for diseases of the central nervous system, such as analgesics, drugs for drug addiction, drugs for schizophrenia, drugs for Parkinson's disease and the like. The preparation method of the compound and its intermediate represented by the following structural formula of the present invention has the advantages of high reaction yield, short reaction time, easy to obtain and relatively cheap raw materials, convenient separation and purification of products, easy control of the reaction, and less generation of three wastes. The advantages of low risk. Because the piperazine compounds are widely used, the present invention has certain practical production significance; . |