http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102775319-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2ddfb4cd4eba362deec8d9b8896ded2d |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-24 |
| filingDate | 2012-06-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4db89e0dea3f12ca0cc717799987ccdf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bcf57cd3ec9928c36d9333b118d52f71 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e55c2ebae614039d85f285a751f23ec http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_75d10fc0d31ef9d62b9dd4ab996a4276 |
| publicationDate | 2014-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102775319-B |
| titleOfInvention | Method for preparing methyldopa through microwave basic hydrolysis 5-methyl-5-(3,4-dimethoxy benzyl) hydantoin |
| abstract | The invention relates to a method for preparing methyldopa or L-methyldopa through microwave basic hydrolysis 5-methyl-5-(3,4-dimethoxy benzyl) hydantoin. Various alkaline aqueous solutions with different concentrations are adopted to hydrolyze 5-methyl-5-(3,4-dimethoxy benzyl) hydantoin under different microwave power and radiation times to prepare DL-alpha-methyl-(3,4-dimethoxy benzyl)-alpha-aminopropionic acid salt which is hydrolyzed in an acid aqueous solution to prepare methyldopa[DL-alpha-methyl-(3,4-dimethoxy benzyl)-alpha-aminopropionic acid] or L-methyldopa[L-alpha-methyl-(3,4-dimethoxy benzyl)-alpha-aminopropionic acid]. When the method is used for hydrolyzing DL-alpha-methyl-(3,4-dimethoxy benzyl)-alpha-aminopropionic acid (or L-alpha-methyl-(3,4-dimethoxy benzyl)-alpha-aminopropionic acid), the molar ratio of a substrate and hydrogen bromide (Hbr) is 1:10-20, and the molar ratio of the substrate and chlorine hydride (HCl) is 1:10-30. The hydrolysis reaction is smooth when acid using amount is big, and disacidify pressure after the hydrolysis reaction is reduced when the acid using amount is small. |
| priorityDate | 2012-06-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 38.