| abstract |
The invention discloses a polypeptide with function of synergistic targeting treatment of nasopharyngeal carcinoma, nanoparticle with function of synergistic targeting treatment of nasopharyngeal carcinoma, and application thereof, and belongs to the field of biological science and drug carrier. The polypeptide comprises a polypeptide with effect of targeting treatment of nasopharyngeal carcinoma, a connecting sequence peptide and a polypeptide for targeting treatment of nasopharyngeal carcinoma and with a helical structure, which are in series connection through covalent bonds. The nanoparticle comprises the polypeptide with function of synergistic targeting treatment of nasopharyngeal carcinoma, phospholipids, cholesterol ester or a loading substance. The polypeptide and the nanoparticle are capable of efficiently and specifically targeting nasopharyngeal carcinoma, significantly inhibit growth of nasopharyngeal carcinoma tumor, and can be applied to clinical treatment. |