http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102766182-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8d453b390b0c4df5df82bb7720bc2a48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dc582bd5d52ab7e1a79e0a8f5cf4d36f |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-16 |
| filingDate | 2011-05-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b9ae6c05daaf207bdc343180d377fb66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9dea3b99d292d9de89aacbd52e871914 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3c1da4789de9a6f8cc607dd576c1f1e0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a79b9d386366c2ed55a223b6120831e6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e0d2f8dba8b455a22b9b059bd516b3c6 |
| publicationDate | 2015-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102766182-B |
| titleOfInvention | Method for synthesizing dideoxynucleoside through glycosyl transfer reaction and application thereof |
| abstract | The invention relates to a method for synthesizing dideoxynucleoside through a glycosyl transfer reaction and an application thereof. The method for synthesizing dideoxynucleoside comprises the following steps of: 1) performing a reaction between dideoxyuridine and a hydroxyl protecting agent to obtain a compound as shown in the formula 1-2 or a compound as shown in the formula 2-2; and 2) performing a reaction of the compound as shown in the formula 1-2 or the compound as shown in the formula 2-2 obtained from the step 1) under the action of a palladium catalyst so as to obtain dideoxynucleoside, namely a compound as shown in the formula 1-3 or a compound as shown in the formula 2-3. According to the preparation method for synthesizing dideoxynucleoside through the glycosyl transfer reaction, the operation method is simple, harsh reaction conditions and complex chemical reaction processes are not required, the disadvantage of low yield of the enzyme catalyzed glycosyl transfer reaction is solved, and the average yield is 80-95%. |
| priorityDate | 2011-05-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 124.