http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102766079-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_10c3f12979e7751f6e54ae5594988766 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4015 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4439 |
| filingDate | 2011-05-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c32e6aa7e2942cdf86edab1e6be9a66f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_996047beb0ef7d632b9c896bf14cae0a |
| publicationDate | 2012-11-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102766079-A |
| titleOfInvention | A class of pyrrolidine derivatives, its preparation method and application |
| abstract | The invention discloses a class of pyrrolidine derivatives as shown in formula I, its preparation method, its application in the preparation of antidepressant drugs and its pharmaceutical composition, wherein, R 1 is C 6 -C 10 aromatic R 2 is a phenyl group, a phenyl group substituted by 1 to 2 halogen atoms, or a C 1 to C 3 alkyl group substituted by 1 to 3 halogen atoms Oxy-substituted phenyl, C 5 -C 6 heteroaryl, C 5 -C 6 heteroaryl substituted by 1 - 2 halogen atoms, 1 - 3 C 1 -C 3 alkoxy A substituted C 5 -C 6 heteroaryl group or a C 1 -C 3 alkyl group substituted by 1-3 C 5 -C 6 heteroaryl groups. The pyrrolidine derivatives of the present invention and pharmaceutically acceptable salts thereof can play a triple reuptake inhibitory effect on 5-HT/DA/NE transporters, and can be used to prepare antidepressants, which can shorten the onset time, enhance curative effect and The reduction of side effects provides a new way for the prevention and treatment of depression, and has better application prospects. |
| priorityDate | 2011-05-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 24.