http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102766072-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_90f807ecdad0d8e70383baf0cddd2c24 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C253-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C255-21 |
| filingDate | 2012-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_15c62da076f5e21c030784b4fa43803d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7553b8ca08deae1c8e145f6eb5c711bc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_07744bc4e02f7b1582e415018969dd15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a45f2ea3dba13156d655811d64b54688 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_187b33c2a6dd76bf0695c3c7b714225b |
| publicationDate | 2013-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102766072-B |
| titleOfInvention | Method for preparing atorvastatin calcium chiral side chain |
| abstract | The invention provides a method for preparing an atorvastatin calcium chiral side chain and belongs to the technical field of drug organic synthesis. The method includes the following steps: 1) under the protection of nitrogen, tertiary butyl acetate and strong base are added in methylbenzene according to molar ratio of 1:1-1.15, temperature rises to 105-110 DEG C slowly, stirring and reaction are performed for 3-7 hours, and thermal insulation is performed for 2-4 hours to obtain a-sodium tert-butyl acetate; and 2) the a-sodium tert-butyl acetate is cooled to the temperature of -30-0 DEG C through a conventional refrigerator, a mixed solution containing compound A and tetrahydrofuran is added in the a-sodium tert-butyl acetate in dropwise mode, molar ratio of original addition of the compound A and the tertiary butyl acetate is 0.3-0.5:1, weight ratio of the tetrahydrofuran and the compound A is 1.0-2.0, dropwide addition is finished in 0.5-2 hours, thermal insulation is performed for 2-4 hours, and a compound B is obtained. The method for preparing the atorvastatin calcium chiral side chain is simple to operate, can improve product yield, avoids liquid nitrogen raw materials which are extremely high in energy consumption during preparation, and achieves effects of energy conservation and emission reduction. |
| priorityDate | 2012-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 36.