| abstract |
The present invention relates to the triazolopyridine derivatives compound of the general formula (I) as monopolar spindle 1 kinases (Mps-1 or TTK) inhibitor, prepare the method for described compound, comprise purposes in the pharmaceutical composition for the preparation for the treatment of or prevention proliferative disease of the pharmaceutical composition of described compound and combination, described compound and for the preparation of the intermediate in described compoundn wherein, Rn 1 , Rn 2 , Rn 3 , Rn 4 and Rn 5 as in specification sheets and claim define. |