http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102757414-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6b33dd6f3ada81a293d6202f04929e5d |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-87 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C55-07 |
| filingDate | 2011-04-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ca2acd75128ae602d07939106cfcad39 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8957739322399659b416620bf8063224 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7f4c9e531cbfb6f3f7881d10698cbd59 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_426e3337c8738cd57d01cc6e890ded92 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a1d601e8f2a08530cce537912012eda1 |
| publicationDate | 2014-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102757414-B |
| titleOfInvention | Preparation method of eseitalopram oxalate |
| abstract | The invention provides a preparation method of eseitalopram oxalate. The method comprises the steps that: S)-4-[4-(dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)-phenyl cyanide is dissolved by using an organic solvent; alkali and methylsulfonyl chloride or p-toluene sulfonyl chloride are added for carrying out a reaction; when the reaction is finished, water is added; an organic phase is separated; oxalic acid is directly added into the organic phase, and the mixture is stirred, such that a solution of eseitalopram oxalate is obtained; and a poor solvent is added for crystallization, such that eseitalopram oxalate is obtained. With the method provided by the invention, a defect of easy degradation of product is overcome. The method is advantaged in simple operation, high yield, and high finished product purity. The method is suitable for large-scale industrialized productions. |
| priorityDate | 2011-04-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 61.