abstract |
The invention relates to the field of medicine related to thrombotic diseases. Specifically, the present invention relates to a class of PAR-1 antagonists containing a benzo five-membered heterocyclic exoimine structure, a preparation method thereof, a pharmaceutical composition containing them and their use in the preparation of drugs for the treatment of thrombotic diseases Applications. Wherein, R 1 , R 2 and R 3 are independently selected from C 1 -C 5 alkyl groups, and X is selected from O and C(CH 3 ) 2 . |