http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102757377-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-20 |
| filingDate | 2012-07-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2014-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102757377-B |
| titleOfInvention | 5-hydroxytryptophan purification method as well as obtained 5-hydroxytryptophan drug |
| abstract | The invention relates to a 5-hydroxytryptophan purification method as well as an obtained 5-hydroxytryptophan drug. The 5-hydroxytryptophan purification method mainly comprises the following steps of: peeling Griffonia seed raw materials; after peeling, adding de-ionized water to carry out leakage extraction at room temperature to obtain a Griffonia seed extracting solution; utilizing an acid to adjust the pH (Potential of Hydrogen) value of the extracting solution and de-coloring by using a de-coloring agent to obtain a Griffonia seed de-coloring solution; concentrating the de-colored de-coloring solution by using an organic film at the room temperature to obtain a concentrated solution; crystallizing the concentrated solution and centrifugally separating a crystal; and drying the crystal in vacuum to obtain the 5-hydroxytryptophan drug. The purity of the obtained 5-hydroxytryptophan drug is more than 99% and the content of a harmful substance 4, 5-tryptophan-diketone is less than 5*10<-5>%; and the recycling rate of a 5-hydroxytryptophan active substance is 70-80%. The purification method disclosed by the invention carries out purification at the room temperature and has the advantages of simplicity in operation and low energy consumption; and organic solvents are not used and the purification method is suitable for industrial production. When the obtained 5-hydroxytryptophan drug is detected according to the current detection technology manner, the harmful substance 4, 5-tryptophan-diketone is not detected. |
| priorityDate | 2012-07-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 29.