http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102755283-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d6a6f422b091ba12ea61d4adbf1b0e8e |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00 |
| filingDate | 2012-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-09-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6d79791f536807a42b565f7761f33d3c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5ae5410d8f3aeda0d7fb44cd73c24578 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_14c86b861f885421e4c3e489e58625f6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7be3d75a0c0f1dd73607808baf04f739 |
| publicationDate | 2013-09-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102755283-B |
| titleOfInvention | Water-in-oil medicament nanodispersion compound thermosensitive hydrogel and preparation method thereof |
| abstract | The invention provides a preparation method of a water-in-oil medicament nanodispersion compound thermosensitive hydrogel. The preparation method comprises the following steps: dissolving a hydrophilic medicament into a part of water to form a water phase solution; dissolving sucrose ethyl erucate in cyclohexane to form an oil phase solution; mixing the water phase solution with the oil phase solution, homogenizing and freeze-drying the mixture, then adding isopropyl myristate to form a water-in-oil hydrophilic medicament nanodispersion; and firstly dissolving hydroxy propyl methyl cellulose in a great amount of remaining water to form a hydroxy propyl methyl cellulose water solution, adding poloxamer 407 to form a matrix, and evenly mixing the matrix with the water-in-oil hydrophilic drug nanodispersion to obtain the water-in-oil medicament nanodispersion compound thermosensitive hydrogel. The preparation process is simple, safe and effective and meets the environmentally-friendly requirement. The invention further discloses a water-in-oil medicament nanodispersion compound thermosensitive hydrogel which can be used for slowly releasing the medicament, and is good in medicament stability and good bioavailability. |
| priorityDate | 2012-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 40.