abstract |
The present invention provides compounds that selectively modulate sphingosine-1-phosphate receptors, including compounds that modulate subtype 1 of S1P receptors. The present invention provides methods for the chiral synthesis of such compounds. The present invention also provides the use of a composition comprising a compound of the present invention, a method of treatment or prevention, and a method of preparation in relation to the treatment or prevention of a disease, disorder or disorder medically requiring modulation of sphingosine-1-phosphate receptors . |