| abstract |
The invention discloses a tumor-targeting living body multimodality imaging and analyzing method based on gold nano-clusters. According to the invention, through an in-vitro cell (including various tumor cells and normal cells) experiment, related cells and chlorauric acid with a certain concentration and a salt solution thereof are incubated under a physiological condition, such that gold nano-clusters are produced; and real-time non-invasive high-resolution tumor cell fluorescence imaging, Raman imaging and ultrasound imaging can be realized. On the basis, a local subcutaneous injection method is adopted, and real-time in-situ living body tumor-targeting fluorescence imaging, Raman imaging and ultrasound imaging are realized on tumor-transplantation nude mice models. With the functional nano-grade probes, multiple functions of tumor targeting, fluorescence imaging, Raman imaging and ultrasound imaging are combined, such that multimodality synchronic monitoring can be realized. Also, with the gold nano-cluster in-situ living body imaging method, accurate positioning and tumor-targeting imaging and analysis can be realized. |