http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102731794-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d281e953d189bcfe2507ba7faba72c25 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G81-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G63-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G63-685 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F8-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F126-04 |
| filingDate | 2012-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-08-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2618565ec6b5447db342f67cfaa2d918 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dacfabc63c402304e21ac050dda34538 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f84b171a940e77fd156ebefff06ec889 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8fc2c45f0d45b73da79a0bd18d99eac1 |
| publicationDate | 2013-08-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102731794-B |
| titleOfInvention | Method for synthesizing poly(N-vinylcaprolactam)/polycaprolactone segmented copolymer |
| abstract | The invention relates to a method for synthesizing a poly(N-vinylcaprolactam)/polycaprolactone segmented copolymer. The employed technical scheme comprises that: moderate alkyne-terminated poly(N-vinylcaprolactam) and azido-terminated polycaprolactone, under the catalysis of sodium ascorbate and blue vitriod, in the mixed solvent of tetrahydrofuran and water, are stirred and reacted for 40-60 h at the temperature of 25 DEG C; rotary evaporation is carried out on the reaction mixture to remove the solvent; anhydrous dichloromethane is used to dissolve the reaction mixture; the dissolved reaction mixture is slowly added dropwise to normal hexane for precipitation; the precipitant is filtered out; and vacuum drying at 30 DEG C is carried out on the precipitant to produce a target product. With the method of the invention, the copolymerization of PNVCL and PCL is realized, and the amphipathic PNVCL-b-PCL segmented copolymer is obtained. The amphipathic PNVCL-b-PCL segmented copolymer can form micelles with kernals and shell structures through self-assembly in water, and has a good application prospect in the fields of controlled drug release, targeted drug delivery, etc. |
| priorityDate | 2012-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 51.