| abstract |
The present invention relates to 4-(substituted anilino)quinazoline derivatives and their preparation method, pharmaceutical composition and application. Specifically, the present invention relates to a compound of formula I or a pharmaceutically acceptable salt or solvate thereof, wherein R 1 , R 2 and R 3 are as defined in the specification and claims. The present invention also relates to the preparation method of the compound of formula I, including its pharmaceutical composition and their pharmaceutical use. The compounds of formula I according to the invention are potent irreversible inhibitors of tyrosine kinases. |