| abstract |
The invention provides a rosmarinic acid derivative which comprises compounds 1-47 and their R-isomers or S-isomers. The structural general formula of the derivative is represented by a formula in the specification; and in the formula, R1, R2, R3 and R4 are defined in the specification. According to in-vitro anti-Mycobacterium tuberculosis experiments of the rosmarinic acid derivative of the invention, a medicine to be detected and a positive contrast medicine are respectively added to a small bottle containing a liquid medium in a continuous two-time dilution manner, a certain bacterium amount of Mycobacterium tuberculosis standard strains H37Rv is inoculated and is cultured for 14 days at 37DEG C, and the minimum inhibitory concentration (MIC) of each medicine to the Mycobacterium tuberculosis is observed. And experiment results show that the compounds in the invention have good anti-Mycobacterium tuberculosis activities, so the compounds can be used for preparing medicines for treating tuberculosis infection, and have large clinical application values. The invention provides a preparation method of the rosmarinic acid derivative. |