http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102727906-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_53b4d53983adbf56dd0e7d0bf96f8ce5 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 |
| filingDate | 2012-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1e0eb28dc6ebcc88858112aa0a8675d0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_96b5b8e55a1631234bcce88ba7d0675c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f9468574c9120ea1d69dd68f03b2bbb9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_314af53f9b56ebdd3260da47f71130f5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d3f71c22ca70627f50d25f98a3b82e63 |
| publicationDate | 2013-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102727906-B |
| titleOfInvention | Clathrates of N-methyl-4-(4-(3-trifluoromethyl)benzoylamino)phenoxyl)nicotinamide and salt thereof, preparation method thereof, and application thereof |
| abstract | The invention belongs to the field of medicine, and specifically relates to clathrates of N-methyl-4-(4-(3-trifluoromethyl)benzoylamino)phenoxyl)nicotinamide and a 4-methylbenzenesulfonate salt thereof, pharmaceutical compositions thereof, a preparation method thereof, and applications thereof. According to the invention, different preparation means are explored for resolving the technical problems of low solubility and low bioavailability of SKLB 610 and SKLB 710. As a result, the bioavailability or the water-solubility of SKLB 610 and SKLB 710 can be effectively improved by the following steps: adopting SKLB 610 and SKLB 710 as an active component; and adding a carrier material such as beta-cyclodextrin (beta-CYD), hydroxypropyl-beta-cyclodextrin (HP-beta-CYD), sulfobutyl ether-beta-cyclodextrin (SBE-beta-CYD), a mixture of two selected from the above, or a mixture of the three is added to the active component, such that a clathrate is prepared. |
| priorityDate | 2011-04-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.