| abstract |
The present invention provides novel sirtuin modulating compounds and methods of their use. The sirtuin-modulating compounds can be used to increase the lifespan of cells, treat and/or prevent a variety of diseases and conditions, including, for example, diseases or conditions associated with aging or stress response, diabetes, obesity, neurodegenerative diseases, Cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing, and diseases or conditions that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent. |