| abstract |
The invention provides the regulator of TNF, especially peptide and derivant thereof, especially GEP peptide, the reaction that its antagonism TNF and TNF mediates, activity or signal transduction.The invention provides antagonism TNF and regulate the disease of TNF mediation or the method for reaction, disease or the reaction of wherein said TNF mediation comprise inflammatory diseases and disease.The invention provides the compositions of GEP peptide, comprise the compositions combined with other inflammatory mediators.The disease that the invention provides treatment, alleviate or prevent TNF to mediate and the method for inflammatory disease, disease and the inflammatory disease of wherein said TNF mediation comprise rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, psoriasis, inflammatory bowel, Crohn disease, ulcerative colitis, uveitis, inflammatory lung disease, chronic obstructive pulmonary disease. |