http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102718739-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a372d24e0173edbc183251f36a6bae4e http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b9dccff33aeb9f1de0fd4f63d6dd8043 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D317-46 |
| filingDate | 2012-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ca8af6a7349a23d15b827d5449dc68e4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e968c7672d2c500443ee6b852b1e1614 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8c5a604ab8b4bd0479005bc58dbaac31 |
| publicationDate | 2013-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102718739-B |
| titleOfInvention | Method for preparing (2S)-2-[[(9H-fluorene-9-yl methoxy) carbonyl] amino]-3-(2,2-dimethyl-1,3-benzo dioxol-5-yl)propionate |
| abstract | The invention discloses a method for preparing (2S)-2-[[(9H-fluorene-9-yl methoxy) carbonyl] amino]-3-(2,2-dimethyl-1,3-benzo dioxol-5-yl)propionate, which mainly aims to solve the technical problems of complicated steps and high operating difficulty in existing synthetic routes. The invention has the technical scheme that levodopa reacts with Fmoc N-hydroxysuccinimide este to obtain Fmoc acyl levodopa; and the Fmoc acyl levodopa reacts with 2,2-dimethoxypropane to obtain (2S)-2-[[(9H-fluoren-9-yl methoxy) carbonyl] amino]-3-(2,2-dimethyl-1,3- benzo dioxol-5-yl)propionate. The solvent used in the reaction of the Fmoc acyl levodopa and the 2,2-dimethoxypropane to obtain the (2S)-2-[[(9H-fluoren-9-yl methoxy) carbonyl] amino]-3-(2,2-dimethyl-1,3- benzo dioxol-5-yl)propionate is tetrahydrofuran; and the catalyst is pyridinium p-toluenesulfonate. The resultant obtained by the method is applied in the field of peptide synthesis as a non-natural amino acid protecting reagent. |
| priorityDate | 2012-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 45.