http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102716085-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e328f3403a32b1dbb56db1d343f262f5 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4745 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-24 |
| filingDate | 2012-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5162cebd8e673a9e453a73eb340a9deb |
| publicationDate | 2013-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102716085-B |
| titleOfInvention | Topotecan hydrochloride liposome injection |
| abstract | The invention discloses a topotecan hydrochloride liposome injection and a preparation method thereof. The liposome injection is prepared from topotecan hydrochloride, cholesterol succinate, lauroyl phosphatidylcholine, polyethylene glycol (PEG) 600, tween 60, trehalose and mannitol in a specific weight ratio. The liposome injection is high in preparation stability; during freezing, liposome is not cracked due to fusion, ice crystals and the like; and after being stored for a long time, the liposome still keeps high entrapment efficiency. The solubility of topotecan hydrochloride and the quality of a preparation product are improved, the toxic and side effects are reduced, the retention time of a medicine in the process of systemic circulation is increased, the bioavailability of the medicine is improved, and the curative effect is improved obviously; and the preparation method is simple, and the topotecan hydrochloride liposome injection is suitable to be industrially produced on large scale. |
| priorityDate | 2012-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 75.