http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102702453-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cc4e13141d402ceb885f368dfa042348 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F293-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F220-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F220-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G63-91 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G63-08 |
| filingDate | 2012-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f6ff9c51e1a6141702739f52a07cda15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d0648485637818285744c0686efc27b8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b1fd3b1dcd9b608b7b7374c2d5f1eead http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7dd76b81f2d131ad52e8c43de8d719a3 |
| publicationDate | 2014-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102702453-B |
| titleOfInvention | pH-responsive 6-arm star block copolymer and preparation method and application thereof |
| abstract | The invention discloses a pH-responsive 6-arm star block copolymer and a preparation method and application thereof. In the structure of the copolymer, pentaerythritol is adopted as a kernel, and each arm is connected with a hydrophobic group, a pH-responsive group and a hydrophilic group. The preparation method comprises the steps of: carrying out ring opening polymerization of the pentaerythritol to obtain a hydrophobic group polymer, carrying out acylation of the end of the hydrophobic group polymer to prepare a macromolecular initiator, carrying out sequential initiation of regeneration of an electron transfer activator for a pH-responsive monomer and the hydrophilic group, i.e. radical polymerization for atom transfer, thereby obtaining the pH-responsive 6-arm star block copolymer. The polymer is self-assembled into nano micelles in aqueous solution, the dissolution of water-insoluble drugs can be enhanced effectively, the polymer can be applied in preparation of a micelle carrying system for water-insoluble anticancer drugs, and the drugs can be released slowly when the pH of normal tissues is 7.4 and rapidly in a controlled way under acidic conditions when the pH of tumor cells is 5-6; and the proportion of functional groups can be easily adjusted, the synthesis process is simple, and the yield is higher. |
| priorityDate | 2012-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 66.