http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102697765-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e328f3403a32b1dbb56db1d343f262f5 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-341 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-194 |
| filingDate | 2012-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5162cebd8e673a9e453a73eb340a9deb |
| publicationDate | 2013-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102697765-B |
| titleOfInvention | Ranitidine hydrochloride/bismuth potassium citrate pharmaceutical composition solid lipid nanoparticles preparation |
| abstract | The invention discloses a ranitidine hydrochloride/bismuth potassium citrate pharmaceutical composition solid lipid nanoparticles preparation and a preparation method thereof. The preparation method includes dissolving water-insoluble lipid in organic solvent to constitute oil phase; taking aqueous solution of ranitidine hydrochloride and hydrophilic surfactant as water phase; loading ranitidine hydrochloride in solid lipid nanoparticles by combining stirring emulsification and high-pressure emulsion homogenizing; mixing with bismuth potassium citrate to obtain ranitidine hydrochloride/bismuth potassium citrate pharmaceutical composition solid lipid nanoparticles; and formulating into solid preparation by conventional method. The preparation is high in drug loading rate, uniform in particle size, and long in drug retention time in blood circulation, and has better sustained-release and controlled-release effects; and facilitates release of bismuth potassium citrate so as to cover on gastrointestinal ulcer surface to exert effect of ulcer isolator. The preparation method is simple in preparation device and easy in operation, improves preparation product quality, reduces toxic and side effects, and is suitable for industrialized production. |
| priorityDate | 2012-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 94.