http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102697720-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e328f3403a32b1dbb56db1d343f262f5 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4745 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34 |
| filingDate | 2012-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5162cebd8e673a9e453a73eb340a9deb |
| publicationDate | 2014-01-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102697720-B |
| titleOfInvention | Irinotecan hydrochloride lipid nanoparticles injection |
| abstract | The invention discloses an irinotecan hydrochloride lipid nanoparticles injection and a preparation method thereof. Mixed phase is formed by dissolving irinotecan hydrochloride and stearic acid in organic solvent and dissolving lecithin in buffer salt solution; aqueous solution of PEG (polyethylene glycol) 400, glycerol and trehalose is adopted as aqueous phase; and then irinotecan hydrochloride is loaded in lipid nanoparticles by combining stirring emulsification and high-pressure emulsion homogenizing to obtain the irinotecan hydrochloride lipid nanoparticles injection. The inventive lipid nanoparticles preparation has the advantages of high drug loading rate, uniform particle size, long drug retention time in blood circulation, better sustained-release and controlled-release effect, simple preparation method and device, easy operation, improved product quality, reduced toxic and side effects, and suitability for industrialized production. |
| priorityDate | 2012-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 49.