| abstract |
The invention discloses a monosaccharide glycopeptide derivative shown as a general formula (I), pharmaceutically acceptable salts thereof and a preparation method thereof. R1 and R2 respectively represent H, CH2-R3 or CH2-R4, and can be the same or not; R3 represents an aromatic group, which is an unsubstituted or substituted benzene ring or biphenyl ring, and a substituent of the benzene ring has one or more halogens, and one or more methoxy groups; and R4 represents C3-C9 saturated aliphatic alkyl. The invention also relates to a synthetic method of the compound shown as a general formula (II). In addition, the invention also provides a pharmaceutical composition containing the monosaccharide glycopeptide derivative and pharmaceutically acceptable salts as active components, and application thereof. The compound and pharmaceutical composition provided by the invention have good antibacterial activity and great significance for development of novel antibacterial medicament. |