http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102690273-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_10f35466bdc1c7cd7325f8ab673666ed |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate | 2012-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_999421d489d195288c13bc6f16e4d32d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bef6008f5b02b196ca5e21275a6daa45 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_acac49f0bd8859ca2367f2e83591e963 |
| publicationDate | 2014-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102690273-B |
| titleOfInvention | Preparation method of sildenafil |
| abstract | The invention provides a preparation method of sildenafil, which comprises the following steps: carrying out condensation reaction on initial raw materials 2-ethoxybenzoic acid and N-hydroxysuccinimide to obtain a compound II, and reacting with 1-methyl-3-propyl-4-aminopyrazolyl-5-formamide hydrochloride to obtain a compound III; after cyclizing and chlorinating the compound III, carrying out nucleophilic substitution reaction with alcohol to obtain a compound IV; reacting the compound IV with chlorosulfonic acid to obtain a compound V; reacting the compound V with N-methylpiperazine to obtain a compound VI; and carrying out hydrolysis reaction to obtain the target compound sildenafil. The invention has the advantages of accessible raw material, stable intermediate, high product yield, low production cost and mild reaction conditions, is simple to operate, and can easily control the reaction conditions of the intermediate; compared with the existing method, the invention has fewer side reactions, and enhances the yield and purity of the product; and the product contains fewer impurities, the purification treatment process is simple and convenient, and thus, the invention has high industrial applicability. The reaction route is shown in the specification. |
| priorityDate | 2012-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 82.