http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102690229-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-18 |
| filingDate | 2011-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102690229-B |
| titleOfInvention | The synthesis of a kind of Menglusitena and prepare intermediate |
| abstract | The present invention provides the synthesis of a kind of Menglusitena and prepares intermediate. The present invention's synthetic route is taking (E)-3-(3-((E)-2-(the chloro-2-quinolyl of 7-) vinyl) phenyl) acryl benzoic ether (5) as raw material, itself and thiocarboxylic acid or its salt are reacted under chiral catalyst catalysis, obtain chiral intermediate, set up the crucial chiral centre of Menglusitena efficiently, chiral intermediate is again through reduction, grignard reaction, and hydrolysis obtains target compound Menglusitena (1); Another is taking (E)-3-(3-((E)-2-(the chloro-2-quinolyl of 7-) vinyl) phenyl) acryl benzene Virahol (6) as raw material; react under chiral catalyst catalysis with thiocarboxylic acid or its salt; obtaining chiral intermediate, chiral intermediate obtains target compound Menglusitena (1) through reduction, hydrolysis again. The raw material of the present invention is easy to get, and reaction conditions is gentle, and easy and simple to handle, catalyzer has satisfactory stability and activity, is easy to reclaim and apply mechanically. The present invention utilizes the method for asymmetry catalysis to introduce the crucial chiral centre of Menglusitena, it is possible to make Menglusitena be convenient to extensive preparation and produce. |
| priorityDate | 2011-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 46.