| abstract |
The invention relates to a temozolomide freeze-dried preparation, which contains a temozolomide active ingredient and at least one solubilizer which can dissolve the temozolomide. The solubilizer used in the preparation may be N(2)-L-Alanyl-L-glutamine, glycyl-L-glutamine monohydrate, glycyl-l-tyrosine, ornithine aspartate or a mixture of the four. The temozolomide preparation prepared by using the technology provided by the invention has the advantages that the solubility of the temozolomide and the stability of the solution are improved; the quality of the solution is stable; the use of the preparation is convenient; and the preparation method is simple and suitable for large-scale preparation. |