http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102688194-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_550246a1a90f3c3034cf90d3392188d9 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P23-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-167 |
| filingDate | 2012-01-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c8a6ca0b38ee15a6d2c143f8caa077f8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eeacee05c9ae30f9b20493117e90e9c5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_740253177d672abe8befc1d432b4f36d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_40dabd579fc6f4879e34aea20205f90a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9db461ed29c800b583a019ac3a7b19d5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_be39b4919209a5dda693650d033e1fd8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bca08ba662f70d9f782448dfa852e5d3 |
| publicationDate | 2014-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102688194-B |
| titleOfInvention | Preparation method of lidocaine ethosome |
| abstract | The invention discloses a preparation method of lidocaine ethosome. The method comprises the steps of: uniformly mixing lecithin, lidocaine and ethanol solution, injecting PBS (Phosphate Buffer Solution), performing ultrasonic processing and filtering and the like. The method adopts a simple prescription and stable technological conditions, is easy to industrialize and has relatively great popularization values. The lidocaine ethosome prepared by the method is stable and has high entrapment efficiency, wherein the maximal entrapment efficiency of the optimized technology can reach 80.93%. The skin irritation test proves that the lidocaine ethosome has good affinity to the skin; the medicated part does not suffer the abnormal phenomena such as erythema, edema and the like; allergic reaction is avoided; and other physiological features are normal. Moreover, the lidocaine ethosome has a strong osmosis promoting effect, can obviously improve the medicine osmosis quantity of lidocaine, and is expected to be developed into novel efficient transdermal local anesthetics for external use. |
| priorityDate | 2012-01-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 33.