http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102675655-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5456846495c5fa8a02f5eaae9faae290 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K33-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G83-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| filingDate | 2012-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_233f0b4d16d3a2873c0610a081adcb7e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3e318327178b234a0c4a9d5204539efe http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_efc26d96c5996a19ff01d932119e23c6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_262d5145bc655a35a9bb4497f9ec2d8d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_642c234d95e92bc277d7c7319f62710b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b33dcf47d25504e1dcaaf440759a3028 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7361c38e4a958386c1e9c1dc926beb67 |
| publicationDate | 2013-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102675655-B |
| titleOfInvention | Water-soluble fullerene and preparation and application methods thereof |
| abstract | The invention relates to water-soluble fullerene and preparing method thereof, can effectively solve the problems of poor solubility, low photosensitive activity and poor biocompatibility of the conventional fullerene, and adopts the technical scheme that water-soluble polymer polyethylene imine is connected to a fullerene molecule through chemical bonds to obtain water-soluble fullerene; and theweight ratio of polyethylene imine to fullerene is 0.08 to 0.12 : 1. The method comprises the following steps: the fullerene is reacted with an ammoniation reagent to obtain amino fullerene; amino fullerene is reacted with aziridine in such a manner that under the existence of protonated hydrogen ions, aziridine is grafted on amino groups continuously; and finally, the polymer of fullerene and polyethylene imine (namely water-soluble fullerene) is obtained. The water-soluble fullerene prepared according to the invention has the advantages that the characteristics of fullerene are not damaged;the water dispersibility is high; the toxicity is low; the stability is favorable; the preparation method is simple; the cost is low; and the water-soluble fullerene serves as a photosensitizer or a medicine carrier during the preparation of medicines curing cancers. |
| priorityDate | 2012-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 89.