| abstract |
The invention discloses a triazole-containing polyethylene glycol protein modifier and its preparation method and application. The general chemical formula is: Wherein, A is a linear alkyl group having 0 to 20 carbon atoms. The modifying agent is prepared from azide-containing monomethoxypolyethylene glycol and alkane derivatives containing terminal alkyne bonds and succinimide through copper-catalyzed click chemistry. The polyethylene glycol protein modification agent containing triazole involved in the present invention can be used for modifying hemoglobin, especially for modifying bovine hemoglobin and human hemoglobin for human body. Various functional groups can be efficiently modified by the method of copper-catalyzed click chemistry, the process is simple, the cost is low, and industrial production is convenient. |