http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102675227-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bffe926681f73580c63f8bbeff581d9f |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D241-08 |
| filingDate | 2012-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_87ba518aaaa1cbb54cc479926ea1a410 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_18d7e0e4957c91084f2248d3ad1854fb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_739b25c762444bbf50a05371956f969d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7234f4ffd0d556799c2b6ea12ffdae02 |
| publicationDate | 2014-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102675227-B |
| titleOfInvention | Preparation method of high-purity dexrazoxane |
| abstract | The invention relates to a preparation method of high-purity dexrazoxane, which comprises the following steps of: (1) cyclization reaction: carrying out cyclization reaction between (S)-1, 2-propane diamine-N, N, N', N'-tetracetic acid or disodium salt of (S)-1, 2-propane diamine-N, N, N', N'-tetracetic acid and formamide, wherein a high boiling point solvent is used; (2) preparation of salt-containing crude product: evaporating the mixture, which is obtained after reaction, for removing the formamide by pressure reduction and concentration, adding organic solvent into the mixture, and filtering to obtain solid; (3) preparation of crude product: adding dioxane into the salt-containing crude product, heating for backflow, filtering, concentrating the filtrate, adding organic solvent into the filtrate to obtain the crude product of dexrazoxane; and (4) refining: adding the crude product of dexrazoxane into N, N'-dimethyl formamide, heating for dissolving, dropwise adding the solvent, carrying out crystallization, filtering to obtain solid, washing the obtained solid with the solvent, drying to finally obtain the high-purity dexrazoxane. The method for synthesizing dexrazoxane is stable in yield and easy in condition control; the product purity is higher than 99.5% and residual organic solvent is little, and the synthesis cost can be reduced. |
| priorityDate | 2012-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 81.