http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102675225-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c23d84d2f6dd5c06aea424c9fb3bc340 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-94 |
| filingDate | 2012-05-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e098ba643412dec5ea0dec836b40ff83 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_31be20fe1cf21b1767482e2739b3c0bc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1e6a05dad417070ea80a29a030e0ab5c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2505cf8474a0c593a93989886aa9ea95 |
| publicationDate | 2012-09-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102675225-A |
| titleOfInvention | A kind of synthetic method of erlotinib hydrochloride |
| abstract | The invention relates to a synthetic method of erlotinib hydrochloride. It has the following process flow: a. Use m-nitrobenzaldehyde as raw material to synthesize m-nitrocinnamic acid; b. Add bromine to obtain 2,3-dibromo-3-(3'-nitrophenyl)propionic acid; c. .Decarboxylation and dehydrobromination to obtain (Z)-β-bromo-(3'-nitrophenyl)-ethylene; d. Reaction with metal hydride to obtain m-nitrophenylacetylene; e. Reduction to obtain m-aminophenylacetylene ; f. Reaction with 4-chloro-6,7-bis-(2-methoxyethoxy)-quinazoline to obtain erlotinib hydrochloride. The method has cheap and easy-to-obtain raw materials, mild reaction conditions, simple operation, high yield, and is suitable for scale-up. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112645826-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107175134-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107175134-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103804201-A |
| priorityDate | 2012-05-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 21.