| abstract |
The present invention relates to the compositions for combination antiviral therapy and purposes, be specifically related to containing [2-(6-Amino-purin-9-base)-1-methyl-ethoxymethyl]-phosphonic acids diisopropoxy carbonyloxymethyl ester (Vireadn ) and (2R, 5S, cis)-4-amino-5-fluorine-1-(2-methylol-1,3-oxathiolane-5-base)-(1H)-pyrimid-2-one (emtricitabine, Emtrivan tM , (-)-cis FTC) and the treatment combination of physiologic function derivant.Described combination can be used for treating HIV, comprises by HIV mutant infection nucleoside and/or non-nucleosidic inhibitors to drug resistance.The invention still further relates to pharmaceutical composition and the preparation of the combination containing described Viread and emtricitabine and physiologic function derivant thereof, and use the Therapeutic Method of this based composition and preparation. |