http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102660551-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2d2ca97152527adfa9e4ac5c2b126a4d |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| filingDate | 2012-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cd330c9ce77327c34321200231d2fe09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_def07b63d20c87352dcfdd6c41cc8ff5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ddc0277a8b9cbfa34b6ecbcb7420b040 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2b93b32f463d7f1ff7579d8aec10ec02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c72a360e7fe326ec5a4642cc3fa05dc5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4f50bffed548ba48fb567ac12729a970 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aca60c77594dc5310596876a2a8e3049 |
| publicationDate | 2014-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102660551-B |
| titleOfInvention | VHH (variable domain of heavy chain of heavy-chain antibody) antibody gene derived from anti-CyPA (CyclophilinA) animal of family Camelidae, encoded polypeptide, and application thereof |
| abstract | The invention relates to VHH (variable domain of heavy chain of heavy-chain antibody) antibody gene derived from anti-CyPA (CyclophilinA) animal of family Camelidae, encoded polypeptide, and application of the gene and the polypeptide in preparing drugs for treating inflammatory diseases such as rheumatoid arthritis. The VHH antibody gene has gene sequence shown in sequence table (400)1, the encoded polypeptide has amino acid sequence shown in sequence table (400)2. Lama pacos as immune animal is used, and phage display techniques (PDT) are adopted to successfully obtain an anti-CyPA VHH antibody capable of specifically combining with expressed CyPA antigen. The antibody can inhibit monocytes THP-1 chemotaxis and gelatinase secretion induced by CyPA. Dimer or polymer can be constructed by gene engineering method, to be applied in diagnosis or research on drugs for treating inflammatory diseases. The gene and the polypeptide establish foundation for further research on related drugs for treating rheumatoid arthritis. |
| priorityDate | 2012-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 231.