http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102659687-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D235-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4184 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 |
| filingDate | 2012-05-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-10-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2014-10-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102659687-B |
| titleOfInvention | Benzimidazolamines compounds as well as preparation method and application thereof |
| abstract | The invention discloses benzimidazolamines compounds shown by general formulas I-V, medical salt of the benzimidazolamines compounds, and a preparation method of the benzimidazolamines compounds; the preparation method comprises the following steps of: stirring 2-chloromethyl-1H-benzimidazole and a compound shown by a general formula VII in an organic solvent for reaction, and controlling the temperature to be within the range of 75-90 DEG C; then, adding an alkali reagent under the stirring condition, controlling the temperature to be within the range of 10-60 DEG C, and stirring for reaction, thus obtaining the benzimidazolamines compound shown in the general formula I; stirring the benzimidazolamines compound shown in the general formula I and compound shown in the general formula VIII, IX, X or XI in an organic solvent for reaction, and controlling the temperature to be within the range of 50-70 DEG C; and after the system is acidic, adding the alkali reagent, controlling the temperature to be within the range of 50-70 DEG C, and stirring for reaction, thus obtaining the compound shown in the general formula II, III, IV or V. The benzimidazolamines compounds and the medical salt of the benzimidazolamines compounds have certain inhibitory activity for gram-positive bacteria, gram-negative bacteria and fungi, thus being used for preparing medicines for resisting bacteria and/ or fungi. |
| priorityDate | 2012-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 186.