| abstract |
The invention provides a spongy asenapine sublingual film agent with micropores and a preparation method thereof. The film agent comprises asenapine, water-soluble macromolecular materials and water-insoluble micro powder dispersed in the water-soluble macromolecular materials, wherein the molecular weight of at least one of the water-soluble macromolecular materials is 10000 to 200000 daltons, and the molecular weight of at least one of the water-soluble macromolecular materials is 200000 to 10000000 daltons. The film agent has a very remarkable effect, the film is quickly dissolved through the macromolecular material with low molecular weight, and the physical strength and the toughness of the film are ensured through the macromolecular material with high molecular weight, so that the aim of quick release is fulfilled and the strength of the film is ensured. |