| abstract |
The invention discloses the application of 2-cyclyl oxygen or sulfur substituted hydroxyacetophenone to treat metabolic diseases. Specifically, it relates to the application of a class of compounds represented by general formula (I) in the preparation of drugs for preventing or treating metabolic diseases. Wherein X is selected from H, NO2 or OH; Y is selected from H or OH; Z is selected from O or S; A ring is selected from alicyclic, heteroalicyclic, aryl, heteroaryl; Z and R can be with A Any suitable connection position on the ring is connected; R represents 1 or more substituents. The metabolic diseases include metabolic syndrome, obesity, diabetes, hyperglycemia, diabetic nephropathy, hyperlipidemia, hypertension, coronary heart disease, atherosclerotic cardiovascular disease, cardiovascular and cerebrovascular diseases, and thus Liver, kidney, and thyroid diseases caused by |