http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102643812-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2011-02-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102643812-B |
| titleOfInvention | The antisense oligonucleotide of people miR-1227 and application thereof |
| abstract | The invention discloses a kind of suppress people microRNA-1227 to express antisense oligonucleotide and application.This antisense oligonucleotide specific binding is in people miR-1227, comprise the sequence with 13 ~ 20 continuous nucleotide complementations in following nucleotide sequence: 5 '-CGUGCCACCCUUUUCCCCAG-3 ', particularly it comprises sequence: 5 '-CUGGGGAAAAGGGUGGCACG-3 '.Antisense oligonucleotide of the present invention can be the mosaic of ribonucleotide, deoxyribonucleotide or ribonucleotide and deoxyribonucleotide, and can modify Nucleotide arbitrary in chain.MiR-1227 antisense oligonucleotide of the present invention can effectively suppress miR-1227 in human glioma cell to express, and suppresses its growth and propagation, thus effectively treats the tumour of cerebral glioma and other miR-1227 high expression levels. |
| priorityDate | 2011-02-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 39.