| abstract |
The present invention provides ansamycin analogs comprising benzoquinones and their use for the treatment or modulation of disorders associated with hyperproliferation such as cancer (formulas (I) and (IV)). The present invention provides ansamycin analogs comprising benzoquinone, wherein benzoquinone is reduced to hydroquinone and captured by reaction with a suitable acid, preferably increasing the aqueous solubility of the resulting (17)-ammonium hydroquinone ansamycin analogs. Air-stable acid. |