http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102633774-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1ce61bf06f294f2f466c067ed41cc8ce http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_53679375fe6921dfec68e5474b17cea4 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4709 |
| filingDate | 2012-03-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f6caf26114179982987820f5aa1d7d7d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_24fb4e2a7ac9112b2b0b59c8ca4e1df3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d5ce7d4492d4c549e17741a48fa321ad http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_da847c0957d2474c56af764fc292a78e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d831572c878b704bc55a5613a64c30fd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_61eac185080b3fc36aba35de00694434 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f3ef6a11a0c1a6d069a9b60ed7c7d214 |
| publicationDate | 2013-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102633774-B |
| titleOfInvention | Methionine or oxidized methionine modified Clinafloxacin and application thereof |
| abstract | The invention discloses methionine or oxidized methionine modified Clinafloxacin, which refers to compounds shown in a formula I, wherein X is SO or SO2; Y is tert-butoxycarbonyl (Boc) or H.HZ, and HZ is HCl or trifluoroacetic acid (TFA); or X is S and Y is H.HCl. The compounds have certain bacteriostasis activity to gram-positive bacteria, such as Staphylococcus aureus, and gram-negative bacteria such as Escherichia coli, saimonella, and pseudomonas aeruginosa. The bacteriostasis activity to Staphylococcus aureus, pseudomonas aeruginosa and saimonella of the compounds TM2-1 (X is S and Y is H.HCl) and TM2-3 (X is SO2 and Y is H.HCl) is approximate to that of Clinafloxacin, and is superior to that of the known compound TM1-1 (X is S and Y is H.TFA). In the compound TM2-3 structure, S is in a maximum oxidation state, so that the compound TM2-3 is high in chemical stability. The Clinafloxacin derivatives can be used for preparing antibacterial medicaments, can provide more efficient and safe candidate medicaments for clinical treatment of infectious diseases, and meets various demands of clinical treatment. |
| priorityDate | 2012-03-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 52.