abstract |
The present invention relates to a class of phthalazinone derivatives and their application in inhibiting the activity of poly(ADP-ribose) polymerase, which has the structure of formula (I). The half inhibitory concentration of the compound of the present invention with the structure represented by formula (I) on poly(ADP-ribose) polymerase is generally below 10 -7 mol.L -1 . The series of compounds can be used for the prevention and treatment of tumors, local ischemic diseases, diabetes and inflammatory diseases. Formula (I) |