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filingDate 2012-03-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2014-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2014-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-102633732-B
titleOfInvention A class of phthalazinone derivatives and their applications
abstract The present invention relates to a class of phthalazinone derivatives and their application in inhibiting the activity of poly(ADP-ribose) polymerase, which has the structure of formula (I). The half inhibitory concentration of the compound of the present invention with the structure represented by formula (I) on poly(ADP-ribose) polymerase is generally below 10 -7 mol.L -1 . The series of compounds can be used for the prevention and treatment of tumors, local ischemic diseases, diabetes and inflammatory diseases. Formula (I)
priorityDate 2012-03-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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