| abstract |
The invention relates to a preparation method of a drug intermediate 2-aminonorbornane, and belongs to the field of fine chemical engineering. In the method, norbornene is used as an initial raw material, and the method comprises the following steps: firstly enabling an organic solvent to react with a borane-tetrahydrofuran adduct at low temperature to prepare norborneol borane; then putting the norborneol borane into ammonia, and uniformly stirring and cooling; slowly dropwise adding a sodium hypochlorite solution, reacting for 6 to 10 hours at a temperature of 15-25 DEG C, and adding inorganic acid into the reaction system; and separating, alkalizing, cleaning, drying and concentrating to obtain the 2-aminonorbornane. The preparation method has the advantages of high reaction speed, high product yield, low production cost, industrial preparation applicability and the like. |