http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102627767-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cc4e13141d402ceb885f368dfa042348 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G73-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2012-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ab44231afc31c5184e594f3a7812adcb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b1fd3b1dcd9b608b7b7374c2d5f1eead http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_80936adc866b5a034a052d40c47edf2a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e23cafa35e9fa70107f14c57d13a46ca http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_896178595086ce820c481a23ccb1ae14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f6ff9c51e1a6141702739f52a07cda15 |
| publicationDate | 2013-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102627767-B |
| titleOfInvention | Potential of hydrogen (pH) response random copolymer based on poly-beta amino ester and preparation method and application thereof |
| abstract | The invention discloses a potential of hydrogen (pH) response random copolymer based on poly-beta amino ester and a preparation method and application thereof. Firstly, polylactic acid with two ends sealed with hydroxide radicals is synthesized through a solution polymerization method, propylene serves as a macro-monomer after acidification, and a pH response amphiphilic copolymer is prepared through the Michael gradual addition reaction. The proportion of functional groups in the polymer molecule can be regulated. The synthetic process is simple, and the production rate is high. By means of a polymeric micelle obtained through a dialysis method and with a hydrophobic group (polylactic acid) and a pH response group (poly-beta amino ester) forming a kernel and a hydrophilic group forming acasing, water slight-solubility anti-cancer drugs can be coated into the kernel of the micelle, and the drugs can be slowly released in low quantity under neutral or weak alkaline conditions and can be quickly and controllably released under weakly acidic conditions. |
| priorityDate | 2012-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 69.