http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102627608-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e6dab0b3344ab01e596a21deac1ce195 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-48 |
| filingDate | 2012-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5c26f3e3731c0926d2f74ad7cf375f17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c74feef0b95a285a05227892e067d44f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cc3ad43e87c77503bd60dff5f99c4c7c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7828a0f97505753f615926237594db4c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d077afbc152350698929f9fd3c48bf86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6637803ae353fba3513266583e331883 |
| publicationDate | 2014-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102627608-B |
| titleOfInvention | Preparation method for analgesic and antipyretic drug-analgin |
| abstract | The invention relates to a new preparation process for an analgesic and antipyretic drug-analgin. In the traditional analgin synthesis path from 4-aminoantipyrine (AA) to analgin, formylation reaction, methylation reaction, hydrolysis reaction and condensation reaction need to be carried out, the yield is low, a large amount of sulfuric acid needs to be used and the environment is polluted. While the new preparation process is as follows: firstly, directly condensing the 4-aminoantipyrine (AA), paraformaldehyde and sodium hydrogensulfite to obtain 4-N-demethylated analgin; secondly, hydrogenating the 4-N-demethylated analgin and formaldehyde in the presence of palladium carbon to generate an analgin crude product of the; thirdly, as the analgin crude product is difficultly purified, hydrolyzing the analgin crude product in alkali condition to obtain 4-methylaminoantipyrine (MAA); and lastly, condensing the 4-methylaminoantipyrine (MAA), the formaldehyde and the sodium hydrogensulfite to generate the analgin. According to the preparation process, the reaction condition is moderate, the yield is high, the sulfuric acid is not used and the three wastes are reduced. |
| priorityDate | 2012-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 54.