http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102626519-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b1b95a0151fe6cf57f119866e3a10c11 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-04 |
| filingDate | 2012-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1d1266e9876df9a19c60f2d814e438ac http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2b391da109f0d9c74f967ceb7debd45b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dd21a838edc4e451d198b22b3f674782 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2989957e791d78e981977107d9aa91b0 |
| publicationDate | 2013-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102626519-B |
| titleOfInvention | Prostatic cancer targeted multifunctional carbon nanotube / polyethylenimine drug delivery carrier, and preparation method and application thereof |
| abstract | The invention discloses a targeting multifunctional carbon nanotube / polyethylenimine drug delivery carrier for prostate cancer. A carbon nanotube with a diameter of 10-20nm and an average length of less than 300nm has carboxyl groups on surface thereof, and is modified by branched polyethylene imine; amino groups on polyethylene imine are utilized to further modify the carbon nanotube by connecting dansyl luminescent groups and human prostate stem cell antigen ( PSCA ) antibody. Method for preparing the material comprises steps of: refluxing the carbon nanotube in concentrated sulphuric acid and concentrated nitric acid to prepare the carbon nanotube with carboxyl groups on surface thereof; and then cladding branched polyethylene imine onto the surface of the carbon nanotube through amide bonds to enable the carbon nanotube with good water solubility and a large number of amino groups on surface thereof; and then attaching sulfonyl groups and PSCA antibody to the surface of the carbon nanotube through the amino groups. The drug delivery carrier prepared by the invention has good biocompatibility, little material toxicity, strong drug load capability, and good luminescent properties and targeting properties. |
| priorityDate | 2012-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 44.