http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102617444-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d6a6f422b091ba12ea61d4adbf1b0e8e |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-584 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-46 |
| filingDate | 2012-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_33ae3613f880cc4e4e1f47617ed7b30a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e918cabef21dc4e160fbc9045d422ae9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_48e2023c7393e4148b66f11c6be8b9aa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_627a47516982b909b4b7e223e5d2a551 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c2cc2851b2f22d3e0ed98fca92c23f8e |
| publicationDate | 2012-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102617444-A |
| titleOfInvention | A metabotropic glutamate receptor enhancer analog and preparation method thereof |
| abstract | The invention discloses a synthetic metabotropic glutamate receptor enhancer analog and a method thereof. That is, mix substituted or unsubstituted o-bromobenzaldehyde with hydrazine, substituted hydrazine and its hydrochloride in an organic solvent in a ratio of 1 to 2:1 in a CO atmosphere, and add 0.5% to 5% of Pd(OAc) 2. After mixing and stirring 0.5%~5% phosphorus ligand, add 2.0~5.0 equivalents of alkali. Under the condition of 1atm carbon monoxide, react at 100~120℃ for 4~24 hours. After the reaction was stopped and cooled, ethyl acetate and saturated saline were added for aqueous extraction, and the organic phase was dried with anhydrous sodium sulfate. After filtration, the filtrate was concentrated, and the target compound was obtained by column chromatography. Compared with the original synthesis route, the raw materials of this method are easy to obtain, the normal pressure reaction, the palladium catalyst consumption is small, the operation is simple, the yield is high, and it is easy to purify. Synthesis of heterocyclic compounds such as isoindolinone and the catalyst can be recycled. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103288711-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103288711-A |
| priorityDate | 2012-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 22.