http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102614118-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5c2122d98634e67d778ff63c5e8905e7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8c50b708d775af93e294cc895900e5ba |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2012-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b54c9d423fb0db8853b2c157c2f7971d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ecba980b0a627f885dc30b61639fb14a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_05771c956448c82f1baaaedb3763fc89 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f4cf4af9a89b74430aa2616942e823f5 |
| publicationDate | 2014-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102614118-B |
| titleOfInvention | Preparation method for epirubicin hydrochloride preparation for injection and preparation |
| abstract | The invention relates to a preparation method for an epirubicin hydrochloride preparation for injection. The preparation method comprises the following steps of: preparing an aqueous solution of epirubicin hydrochloride; degerming and filtering; filling; and freeze-drying. When the aqueous solution of epirubicin hydrochloride is prepared, an acid pH regulator is adopted for regulating the pH value of the aqueous solution of epirubicin hydrochloride to 3.2-4.5, and the aqueous solution of epirubicin hydrochloride is heated and subjected to heat preservation at the temperature of between 40 and 80DEG C for 30 to 120 minutes. The invention also provides an epirubicin hydrochloride preparation for injection prepared by the method. The preparation method for the epirubicin hydrochloride preparation for injection is simple, and easy to implement; and an epirubicin hydrochloride product prepared by the method has the dimer impurity of less than 0.2 percent and the total impurities of not more than 1 percent, the quality of the product is far superior to stipulations of the pharmacopeia that the single impurity is not more than 0.8 percent and the total impurities is not more than 2.5 percent, and the quality and the safety of the product are obviously improved. |
| priorityDate | 2012-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Total number of triples: 18.