http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-102605034-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_264e7f6c4e9cf574df7a0818f65a455c |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P7-62 |
| filingDate | 2012-02-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_869e194d6490e04f0c43894460d0eaac http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_29623d8b4728efe9d23e8589e835c061 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c188273e16047eb1cc3f5e0b588206f0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f32cb26e85e0bd32875e293c60f77bf0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7f20629b6fcf7207a622aad02622d3e9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bf257646d2fbb389f3755c3a24fc680d |
| publicationDate | 2014-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-102605034-B |
| titleOfInvention | Biological enzyme resolution method for preparing optically pure (S)-5-(4-fluorophenyl)-5-hydroxypentanoate |
| abstract | The invention discloses a biological enzyme resolution method for preparing optically pure (S)-5-(4-fluorophenyl)-5-hydroxypentanoate. The method uses fluorobenzoyl butyrate to synthetize (S)-5-(4-fluorophenyl)-5-hydroxypentanoate by methyl esterification and chemical reduction, then uses immobilized lipase to carry out enantioselective resolution to obtain enantiomerically pure (S)-5-(4-fluorophenyl)-5-hydroxypentanoate and (R)-5-(4-fluorophenyl)-5-acetoxypentanoate. The invention also provided a method for preparing p-fluorobenzoyl butyric acid by racemization through hydrolysis and oxidation of (R)-5-(4-fluorophenyl)-5-acetoxypentanoate, and the method realizes cyclic utilization of a by-product. The method provided by the invention is low in cost, high in yield and optical purity and environment-friendly, and is suitable for industrial production of (S)-5-(4-fluorophenyl)-5-hydroxypentanoate. |
| priorityDate | 2012-02-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 107.