| abstract |
The invention discloses a biological enzyme resolution method for preparing optically pure ( S )-5-(4-fluorophenyl)-5-hydroxypentanoic acid methyl ester. The method synthesizes ( RS )-5-(4-fluorophenyl)-5-hydroxypentanoic acid methyl ester from p-fluorobenzoylbutyric acid through methylation and chemical reduction, and then utilizes immobilized lipase enantioselective Resolution afforded enantiopure ( S )-5-(4-fluorophenyl)-5-hydroxyvaleric acid methyl ester and ( R )-5-(4-fluorophenyl)-5-acetoxyvaleric acid methyl ester. The present invention also provides ( R )-5-(4-fluorophenyl)-5-acetoxyvaleric acid methyl ester through hydrolysis, oxidation, and racemization into p-fluorobenzoyl butyric acid, so that the by-product can be obtained Recycling. The method provided by the invention has the characteristics of low cost, high product yield and optical purity, and environmental friendliness, and is suitable for industrial production of optically pure ( S )-5-(4-fluorophenyl)-5-hydroxypentanoic acid methyl ester. |